Effectuation of Pleurotus pulmonarius on Hypercholesterolemic Wistar-Kyoto Rats: Analysis on Liver and Sera

Hypercholesterolemia is one of the potential risks cardiovascular heart disease (CHD). An early diagnosis and treatment attenuate risk CHD. Besides statin prescription for hypercholesterolemia, functional food has an added value to ameliorate risk. This study was conducted analyse significant effect grey oyster mushroom (Pleurotus pulmonarius) on hypercholesterolemia. Thirty-six Wistar-Kyoto rats were assigned into six groups, consisted normal (N), hypercholesterolemia (H), two groups prevention (P1 P2), (T1 T2). For purpose, P1 P2 concomitantly induced be hypercholesterolemic fed with either crude aqueous extract P. pulmonarius (CA) or simvastatin 45 days. Following days hypercholesterolemic-induction, T1 T2 then orally CA another 30 On day 45, N, H, P1, sacrificed, whereas sacrificed 75. Histopathology examination showed conditions liver tissues. Fat droplets observed in hepatic tissues also remained belonged groups. The tissues’ viability better suggesting compound(s) present might able protect them from further damage. Metabolomic analysis sera altered regulation several metabolites such as pantothenic acid, N-carbamylglutamate, serotonin ceramide against control group.